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- dko小鼠的病理生理學表現與DMD極為相像,是DMD臨床治療研究的理想疾病動物模型。The pathophysiology of dko mouse was very similar to Duchenne muscular dystrophy (DMD), and dko mouse is an ideal animal model for study of DMD clinical therapy.
- 目的觀察Duchenne型肌營養不良症模型DKO小鼠經骨髓間質幹細胞(MSC)移植治療后肌組織的超微結構改變情況。Objective To observe the ultrastructural changes in the muscular tissues of Duchenne muscular dystrophy mouse models with dystrophin/utrophin double-knockout (DKO) after transplantation of bone marrow-derived mesenchymal stem cells (MSCs).
- 目的 系統研究 C5 7鼠、mdx鼠、dystrophin/ utrophin基因雙敲除 (dko)鼠運動功能、生化、病理等方面的差異 ,為假肥大型肌營養不良症 (DMD)的進一步研究提供可靠依據。Objective With a view to further experimental studies on Duchenne muscular dystrophy (DMD), we investigated the motor function,serum creatine kinase (CK) level and pathological characteristics of muscular tissue in C57,mdx,dystrophin/utrophin gene double knockout (dko)mice.