Somatic alterations within the oncogenome underlie the genesis and progression of most human tumors, by causing oncogene activation or tumor suppressor gene inactivation. 摘要大部分人類腫瘤是由基因組中的體細胞性改變所導致的癌基因激活或抑癌基因失活所引發的。
Cancer gene discoery has relied extensiely on analyzing tumors for gains and losses to reeal the location of oncogenes and tumor suppressor genes, respectiely. 癌症基因的發現在很大程度上依賴於對腫瘤的獲得或丟失基因進行分析以定位癌基因和抑癌基因。
