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- Objective To investigate the effect of bcr abl fusion gene on CML cell apoptosis. 目的研究bcr?abl融合基因在慢性粒细胞白血病细胞(CML)凋亡调控中的作用。
- The results showed that better reaction conditions were gained by exploration of hybridizotion temperature and elution conditions, bcr abl fusion gene in leukemia cells was detected by prepared miccroarray. 结果表明 :通过对不同杂交温度、洗涤条件等的探索获得了较好的反应条件并用制备的芯片检测出了细胞株中的bcr abl融合基因。
- Method:The fragement of Bcr abl fusion gene was amplified from K562 cells of CML by RT PCR and was cloned into the downstream of GST gene in pGEX 6P 1 vector according to the current open reading frame. 方法 :以慢性粒细胞白血病 (CML)K5 6 2细胞株总RNA作为模板 ,采用RT PCR方法扩增包含Bcr abl(b3a2 )融合位点周围的基因片段。
- Expression of fusion gene in transfected COS 7 cells was justified. 重组质粒转染COS 7细胞后经检测证实 ;该融合基因能在真核细胞中表达 .
- Uncommon bcr/abl fusion gene may occur in typical Ph(+) CML patient. 少见型bcr/abl融合基因可见于典型Ph染色体阳性CML患者并产生异常的RT PCR扩增带。
- The transfected cells expressed IL-18 fusion gene and 18 kD IL-18 protein. IL-18转染细胞表达IL-18融合基因及18 kD蛋白。
- Conclusion: 1.bcr/abl fusion gene was the molecular hallmark of CML. 2. 结论:1、bcr/abl融合基因mRNA可作为慢粒患者的特征性的基因诊断标志。
- Induction of CTL by immunization of bcr abl fusion gene bcr-abl基因免疫诱导特异性细胞毒性T淋巴细胞杀伤功能
- Inhibition of apoptosis by bcr abl fusion gene in K562 cells bcr-abl融合基因抑制K562细胞凋亡的研究
- These transgenic pigs were analyzed in terms of the hersdity of the fusion gene. 通过传代进行转基因的遗传分析。
- The bcr-abl fusion gene is the characteristic gene of chronic myeloid leukemia (CML). 慢性粒细胞白血病(Chronic myeloid leukemia,CML)具有特征性的bcr-abl融合基因。
- The bcr/abl fusion gene positive DCs (CML DCs) were induced from the PBMCs of patients with CML. CML患者PBMCs在体外可诱导生成bcr/abl融合基因阳性的DCs(CMLDCs)。
- Study on the Detection of PML/RARA fusion gene by FISH and FCM in APL and its clinical application. 应用FISH、FCM检测APL PML/RARA融合基因及临床应用的研究
- Objective:To investigate the value of detection of Ph chromosome and bcr/abl fusion gene in the diagnosis of CML. 目的 :观察Ph染色体 ,bcr/abl融合基因与慢性粒细胞白血病 (CML)的诊断指标。
- The constructed eukaryotic expression vector contained gB680 and pp65m fusion gene and expressed in COS-7 cells. 重组质粒含有gB680和pp65m融合基因,并能在COS-7细胞中表达。
- The BCR/ABL fusion gene plays an important role in the malignant transformation of chronic myelogenous leukemia (CML). 融合基因 BCR/ABL在慢性粒细胞白血病的恶性转化过程中起着主导作用 .
- Methods The bcr/abl fusion gene mRNA levels of 337 CML patients were detected by RT-PCR. 方法采用巢式逆转录PCR(RT-PCR)检测337例CML患者bcr/abl融合基因的表达,并对所有患者进行残留病灶的动态监测,共检测632人次。
- Gpd-Tp92 fusion gene constructed in pcDNA3.1 (+) vector could express a fusion protein in Hela cells. pcDNA3.;1(+)/Gpd-Tp92在HeLa细胞中能有效表达。
- A fusion gene is reported to be responsible for the hypereosinophilia in myeloproliferative subtype of HES. 骨髓异常增殖型嗜酸细胞增多综合征因出现融合基因导致嗜酸粒细胞的增多。
- Objective To investigate the expression of AML1/ ETO fusion gene mRNA in acute myeloid leukemia( AML) and its clinical significance. 目的了解急性髓系白血病中AML1/ETO融合基因表达情况及相关临床意义。