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- Most members of the XRCC genes family participated in several DNA repair pathways, including base excision repair, homologous recombination repair and non-homologous end joining. 目前已鉴定的这一基因家族的多数成员均参与几种重要的DNA修复途径,包括碱基切除修复、同源重组修复和非同源末端重接。
- BACKGROUND & OBJECTIVE: Adenosine diphosphate ribosyltransferase (ADPRT) and X-ray repair cross-complementing 1 (XRCC1) are 2major DNA base excision repair (BER) proteins and act interactively instimulating and executing BER processes. 背景与目的:DNA修复缺陷是肿瘤的遗传易感因素。 二磷酸腺苷核糖转移酶(adenosinediphosphateribosyltransferase,ADPRT)和X线修复交叉互补蛋白1(X-rayrepaircross-complementing1,XRCC1)是碱基切除修复的重要成分。
- Inhibitor of base excision repair 碱基切除修复抑制剂
- base excision repair (BER) 碱基切除修复
- Base excision repair 碱基切除修复
- Our results provide evidence for a coupled mechanism of 5-meC demethylation, whereby AID deaminates 5-meC, followed by thymine base excision by Mbd4, promoted by Gadd45. 如果可以的话,它将能导致新的药物来恢复特定基因活性并抑制肿瘤生长。引人注目的是,这一系统也能帮助基因组免遭突变。
- Previous studies have shown that sustained ERK1/2 activation elicited by lead acetate (Pb(II)) enhances nucleotide excision repair synthesis and confers anti-cytotoxicity and anti-mutagenicity. 先前研究发现,醋酸铅能藉由持续性活化之ERK1/2讯号而增加核苷酸切除修补能力及降低细胞毒性及基因突变。
- excision repair deficient mutant 剪切突变型
- Nucleotide Excision Repair and Human Disease 核苷酸切除修复和人类疾病
- Excision repair cress-complementation group 1 核苷酸切除修复交叉互补组基因蛋白
- Excision repair cross-complementation group 1 切除修复交叉互补基因1
- Excision repair cross-completion 1 gene 切除修复交叉互补基因1
- excision repair cross-complementing gene 1 (ERCC1) 切除修复交叉互补基因1
- excision repair cross-completion gene 1 修复交叉互补基因1
- The runner was retired put out at first base. 跑垒者于第一垒上被刺杀出局。
- The runner went to second base on a wild pitch. 一记瞎设让跑垒员跑上了第二垒。
- You cannot enter a military base without a permit. 无通行证者不得擅入军事基地。
- Excision repair cross - complementing gene 1 ( ERCCI ) 切除修复交叉互补基因1
- Her heavy industry rests on a broad and firm base. 它的重工业有广泛坚实的基础。
- excision repair cross complementing rodent repair deficiency 纠正鼠突变细胞切除修复缺陷