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- RESULTS&CONCLUSIONS:Aristolochic Acids Chinese herbal medicines should be used sen-sibly,practically and rationally. 结果与结论:对待含马兜铃酸类中药应当持理性态度,实事求是,合理用药。
- OBJECTIVE:To lead to a rational recognition and use of Chinese herbal medicines containing aristolochic acids. 目的:引导正确认识及应用含马兜铃酸类中药。
- The method of HPLC/MS analysis of aristolochic acid A (Aris A A) in Chinese traditional patent medicine(CTPM) was established. 建立了中成药中马兜铃酸A的高效液相色谱/质谱检测方法.
- RESULTS: Aristolochic acid has nephrotoxicity,alimentary canal toxicity,carcinogenicity,mutagenicity and genotoxicity. 结果:马兜铃酸具有肾毒性、消化道毒性、致癌性、致突变性和基因毒性。
- Object: To compare the content of Aristolochic acid of different parts in Asarum heterotropoides Fr. 目的:比较不同产地不同部位辽细辛中马兜铃酸的痕量。
- Results The main ADR related to aristolochic acid is nephropathy, urothelial cancer being found on some patients. 结果与马兜铃酸有关的不良反应主要为肾损害,部分病例出现尿道上皮癌。
- Some traditional Chinese medicines (TCM) containing aristolochic acids (AA) will cause Aristolochic Acid Nephropathy (AAN), and this phenomenon has being paid important attention. 某些含马兜铃酸的中药会引起马兜铃酸肾病,这一现象已引起了人们的广泛关注。
- Cosyns J P,Dehoux J P,Guiot Y.et al.Chronic aristolochic acid toxicity in rabbits:A model of Chinese herbs nephropathy.Kidney Int,2001,59:2164. 文晓彦;郑法雷;高瑞通;等.;马兜铃酸I诱导人肾小管上皮细胞转分化的作用
- Objective: To investigate the urinary carcinoma in patients with aristolochic acid nephropathy (AAN), in order to improve the levels of diagnosis. 摘要目的：探讨马兜铃酸肾病患者伴发泌尿系肿瘤情况，提高认识和诊断水平。
- To analyse the 44 cases of aristolochic acid nephropathy (AAN) in term of pathogeny, clinical symptoms, laboratory results, and some renal pathology. 摘要从近6年收治的肾小管间质性疾病中，筛选出马兜铃酸肾病患者44例。
- OBJECTIVE To determine the content of Aristolochic Acid A in different parts of Herba cum Radice Asari and in Xuetie Dingchuan Plaster. 目的测定细辛不同药用部位及其制剂中马兜铃酸A的含量。
- This paper reviewed TCMs containing aristolochic acids, the toxicity of aristolochic acids, the pathogenesis and reasons for aristolochic acid nephropathy. 文章综述了含马兜铃酸的中药、马兜铃酸的毒性作用、马兜铃酸肾病发病机制及其原因。
- Objective:To investigate the urinary carcinoma in patients with aristolochic acid nephropathy(AAN),in order to improve the levels of diagnosis. 目的:探讨马兜铃酸肾病患者伴发泌尿系肿瘤情况,提高认识和诊断水平。
- Method Searching published literatures and website associated with aristolochic acid toxicities both domestic and abroad and analyzing them. 方法通过检索国内外公开发表的文献和各国官方网站,收集与马兜铃酸有关的不良反应病例,分析其安全性。
- This paper has studied the structure,method of measurement and clinical application of Aristolochic acids,and also discussed the aristolochic acid nephropathy(AAN). 对马兜铃酸类的结构、检测方法、临床应用及其毒副作用进行了分析,并对马兜铃酸肾病进行了讨论。
- To follow therapeutic effect and adverse reaction of Aristolochic acids researches, the nephrotoxicity of some Chinese herbs that contain Aristolochic acids has been revealed. 随着有关马兜铃酸成分疗效和副作用研究的不断深入，其肾毒性逐渐被揭示，而研究认为这种肾毒性主要来源于马兜铃酸A。
- Results and Conclusion It should pay much attention to be doubted contained materials of aristolochic acids from medicinal plants and Chinese patent medicines. 结果和结论对怀疑含有马兜铃酸类物质的药用植物和中成药的检测应引起重视。
- Gao YL, Chen YP, Dong HR, et al. Experimental study on renal interstitial fibrosis of chronic aristolochic acid nephropahty in rats. Chin J Nephrol2005;21(1):31-35. 高艳丽;谌贻璞;董鸿瑞;等.;慢性马兜铃酸肾病肾间质纤维化发病机制的初步探讨
- Result:aristolochic acid was founded in 6 species of Aristolochia,and not in the other species of Asarum,Akebia,Clematis,Sinomenium,Stephania,Vladimiric and Aucklandic geneses. 结果:17种相关中药材仅马兜铃属6种可检测出马兜铃酸类成分。 细辛属(Asarum)、木通属(Akebia)、铁线莲属(Clematis)、风龙属(Sinomenium)、千金藤属(Stephania)、川木香属(Vladimiric)及云木香属(Aucklandic)相关植物中均未检出相应成分。
