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- Applying antisense oligonucleotide to block the expression of CLC-3 mRNA. 应用反义核酸的阻断CLC一3 mRNA在细胞中的表达。
- Antisense oligonucleotide (4 ug/mL) can decrease the content of CLC-3 mRNA and make no influence on cell cycle. ASO(4林留mL)可以减少细胞CLC一3 mRNA的含量,不
- On the other hand, antisense oligonucleotide of FAK was used to block its expression. 使用反义寡核苷酸阻断FAK的表达,达到下调信号通路的作用。
- Objective In order to study specific antiviral effect of antisense oligonucleotide (ASON). 目的探讨反义寡核苷酸(ASON)特异性抗病毒作用。
- Objective:To reveal the possibility of antisense oligonucleotide of telomerase used as an effective agent for tumor prevention. 目的:探讨端粒酶反义寡核苷酸对二甲肼诱导大鼠大肠癌的预防作用。
- When the rats were repeatedly treated with antisense oligonucleotide to block synthesis of OFQ receptor, pain threshold increased significantly. 但两种剂量的0FQ阴无论是脑室还是鞘内给药,均可对抗电针镇痛;
- Using specific antisense oligonucleotide as probe to selectively inhibit the gene express of receptor is a effective means for the analysis of receptor functions. 但由于其抑制效率及适用范围的不足限制了其广泛应用。
- To research if the anti-cancer activity of DDN is p73 related. Contrasted by the missense oligonucleotide(MSODN) and DDN alone,we interference the effects of DDN(15uM) with TAp73-specific antisense oligonucleotide(ASODN). 选取一DDN药物较佳作用浓度(15uM)处理hela细胞,同时运用3条针对不同部位的TAp73特异性反义寡核苷酸进行干预,并以错义寡核苷酸干预组和DDN药物单独处理组为对照:运用RT-PCR方法验证我们对于TAp73/DNp73表达相对量的干预效果;
- Antisense oligonucleotide with hTR MNP-端粒酶反义核酸复合物
- Antisense oligonucleotide (ASON) 反义寡核苷酸(ASON)
- antisense oligonucleotide (ASODN) 反义寡核苷酸
- Apoptosis of drug-resistant human ovarian cancer cell line COC_1/DDP induced by survivin antisense oligonucleotides. Survivin反义寡核苷酸诱导人卵巢癌耐药细胞株COC_1/DDP凋亡的实验研究
- Objective To study antiviral effect of Lihposome-mediated antisense oligonucleotides COS-ASIN. 目的 研究脂质体介导的反义寡核苷酸在体外对乙型肝炎病毒基因复制和表达的抑制。
- Antisense oligonucleotides have been successfully employed to inhibit and modulate specifically gene expression. 反义寡聚核苷酸已成功用于对基因表达的特异性调控与抑制。
- Objective To study inhibition of VEGF expression in human bladder carcinoma cells by antisense oligonucleotides. 目的观察VEGF反义寡核苷酸对膀胱癌细胞VEGF表达的抑制情况。
- "As compared to conventional drugs that work on proteins, antisense oligonucleotides work on RNA. 与传统的作用于蛋白质的药物相比,反义寡聚核苷酸作用于RNA。
- Until now,several methods have been developed to improve the intracellular delivery of antisense oligonucleotides. 到目前为止,已发展了数种提高寡聚核苷酸类化合物细胞内转运的方法。
- Including antisense oligonucleotides, ribozymes, at the wrong virus interferents, such as cell suicide gene. 包括反义核苷酸、核酶、缺陷病毒的干扰剂、细胞自杀基因等。
- Survivin antisense oligonucleotides could effectively induce apoptosis of drug-resistant human ovarian cancer cell line COC1/DDP. survivin ASONs反义寡核苷酸能诱导人卵巢癌耐药细胞株COC1/DDP细胞凋亡 ,且效果显著
- HSP 70 antisense oligonucleotides could not only inhibit the proliferation,but also induce the apoptosis of Eca-109 cells. HSP70反义寡核苷酸能抑制Eca-109细胞的生长并诱导其发生凋亡。