and increased by the treatment of Radix Rehmanniae, Cortex Moutan.Tyrosinase activity increases in ethanol extract and decreases in water extract of Rhizoma Alismatis.

• 六味地黄丸组方中药熟地黄、牡丹皮使酪氨酸酶活性增高，茯苓、山药、山茱萸使酪氨酸酶活性降低，泽泻组醇提物增高，水提物降低。