and BALB/C mice were subcutaneously injected with mixture phages clones. Sera Sm antibody,anti-double stranded DNA(dsDNA)antibody,and antinuclear antibody(ANA)of mice were detected using direct immunofluorescence;

• 进而用混合噬菌体阳性克隆皮下免疫BALB/C小鼠,ELISA法检测小鼠血清IgG型抗Sm抗体、抗双链DNA(dsDNA)抗体和抗核抗体(ANA)水平;