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- anaphylatoxin C5a 过敏毒素C5a
- At present most inhibitors of C5a anaphylatoxin competed with C5a for binding to C5a receptor(C5a R) can effectively depress the activity of C5a . 目前的C5a抑制剂大多以C5a受体(CD88)为靶位,通过与C5a竞争性结合CD88而达到抑制C5a生物活性的目的。
- The antisense peptides of the C5a could inhibit the C5a anaphylatoxin function that induced ICAM 1 expression, and could decrease the MPO activity of the adhesion PMN cell. 髓过氧化物酶 (myeloperoxi dase ;MPO)为单核细胞PMN所特有 ;其活性可以间接反映C5a趋化白细胞的能力 ;C5a刺激血管内皮细胞表达胞间粘附分子 (ICAM 1)、血管间粘附分子 (PCAM 1)等 ;后者能增加对PMN的粘附 ;检测MPO活性可间接反映出C5a的功能 .
- The increase of complement C5a in CPB is close correlated to endothelial cells activation fast phase. 目前认为内皮细胞激活可分为两个时相：第一时相主要是补体活性成分诱发的快速相，体外循环时补体活性成分C5a水平的提高与内皮细胞激活快速相的发生密切相关。
- This material shall be supplied with 1/2 weight of C5A core plate to provide antisticking caused by heat treating. 这种材料应与热处理供应给1/2重量因防粘剂所造成的的C5A核心板中。
- Objective To predict binding domains of human C5a like receptor 2(C5L2) and further to detect the affinity between C5a and C5L2 by the technology of bioinformatics and BIA. 目的通过生物信息学分析人C5L2受体的配体结构域,并进一步利用生物分子相互作用测定技术(biomo-lecular interaction analysis,BIA)研究其与配体C5a分子间的相互作用。
- This material shall be supplied with 1/2 weight coating identified as C5A core plate to provide antisticking of laminations after oil burn-off treatment. 此提供的材料必须是1/2重的涂层，作为C5A芯板，以提供油燃烧处理后抗粘着的积层。
- AIM: To observe the expression and distribution of C5a receptor(C5aR) on epiretinal membranes (ERM)tissue from patients with proliferative retreous body retina ( PVR) lesion and cultured retinal pigmentary epithelial (RPE) cells. 目的 :检测手术中取出的增生性玻璃体视网膜 (PVR )病变患者的视网膜前膜 (ERM )组织及培养的人视网膜色素上皮细胞 (RPE )中的C5a受体 (C5aR)的表达及分布 ,阐明C5a受体在发生PVR的病理过程中可能的作用。 方法 :手术取出ERM组织 ,常规制备石腊切片。
- The "classical" chemoattractants include bacterial peptideN-formyl-methionyl-leucyl-phenyl-alamine (fMLF), activated complement components (C3a and C5a), leukotriene B4 (LTB4) and platelet-activating factor (PAF). 经典的趋化物质包括细菌来源的氮端甲酰化的甲硫氨酰-亮氨酰-苯丙氨酸(fMLF)，活化的补体成分(C5a)，白三烯B4(LTB4)和血小板活化因子(PAF)。
- C5L2 plays a role in the disease involved in anaphyltoxin C5a and has significance for the study of G protein coupled receptor. C5L2 is also a valuable tool for studying the biological activities of C5a and C5a des Arg74. 作为过敏毒素受体,C5L2在过敏毒素C5a参与的相关疾病,如脓毒症(sepsis)、急性肺损伤(ALI)、急性呼吸窘迫综合征(ARDS)等的发生、发展以及对G蛋白偶联受体的研究都具有重要的意义。
- C5a is the activator of endothelial cells expression adhesion molecule P-selector, which can be expressed on the surface of those cells, triggered adhesive response of PMN and endothelial cell surface. C5a是内皮细胞表达粘附分子P-选择素的激动剂，而P-选择素在内皮细胞激活时能迅速经细胞排列作用表达于内皮细胞表面，触发中性粒细胞(PMN)在内皮细胞表面的粘附反应。
- Keywords C5a;Antisense peptide;Sepsis; 反义肽;脓毒症;
- Keywords C5a;C5L2;binding domain;biomolecular interaction;biosensor; C5L2蛋白;配体结合域;生物分子相互作用;生物传感器;
- Keywords C5a;Antisense peptide;Biomolecular interaction;Affinity;BIA technology; 反义肽;生物分子相互作用;动力学分析;生物传感器;
- Keywords C5a;C5aR;Sepsis;Inflammation mediators;Coagulation pathways;Polymorphonuclear neutrophils;Multi-organs dysfunction syndrome; 脓毒症;炎症介质;凝血通路;中性粒细胞;多器官功能障碍综合征;
- anaphylatoxin inactivator 过敏毒素灭活剂
- anaphylatoxin inhibitor 过敏毒素抑制剂
- anaphylatoxin(s) 过敏毒素
- classified anaphylatoxin 过敏毒素分类
- anaphylatoxin 过敏毒素
