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- allosteric ribozymes 别构效应核酶
- Allosteric enzymes may have more than one modulator. 它可以有一个或多个调节物。
- allosteric ribozyme 别构核酶
- Allosteric enzymes possess an allosteric site in addition to their ACTIVE SITE. 别构酶控制着别构部位和它的活性部位。
- The small molecule causing the conformational change is an allosteric effector. 引起结构变化的小分子叫做变构效应
- Proteins which have two separate but interacting sites are called allosteric proteins. 这种具有两个不同而又相互作用位置的蛋白质叫做变构蛋白质。
- Allosteric site A part of an enzyme to which a specific effector or modulator can be attached. 别构部位:可以结合特定效应物或者调节物的酶的一个部分。
- Proteins which have two separate but interacting kinding sites are called allosteric proteins. 这种具有两个不同位置而又相互作用的蛋白质叫做变构蛋白质。
- Recently developed small chemical compounds activate GK by binding to an allosteric site of the enzyme protein. 新近开发的一类小分子化合物与该酶蛋白一个变构位点结合从而激活GK。
- Including antisense oligonucleotides, ribozymes, at the wrong virus interferents, such as cell suicide gene. 包括反义核苷酸、核酶、缺陷病毒的干扰剂、细胞自杀基因等。
- Obviously the involvement of "allosteric effects" in the action of growth regulators is highly specific and equally speculative. 在生长调节剂的作用中涉及“变构效应,”这显然是高度特殊又是高度推测性的。
- Many oligomeric proteins are allosteric and known to be self-condensing and play an important role in metabolic control. 许多低聚物蛋白是变构的并且是能自我压缩的,在对于新陈代谢中起着重要的作用。
- But APV and MK-801 were toxic inthemselves, Kyn as an endogenous allosteric antago-nist of the N-methyl-D-asl)artate receptor is low intoxicity. 但APV和MK-801本身有一定毒性。
- A small molecule that when bound to the allosteric site of an enzyme causes either a decrease or an increase in the activity of the enzyme. 效应物,一种小分子,当邻接酶的变构点时会引起酶活动的增加或减少。
- The RNA molecules act as RIBOZYMES, catalyzing both the splicing process ad the assembly of the spliceosomes.See transcription. 其中RNA分子起核酶的作用,催化剪切过程和剪接体的组装过程。
- The only successful study of ribozymes against HBV in cells was shown in a stable transfectant that endogenously produced hairpin ribozymes. 唯一在细胞内核酶成功抑制HBV的研究是转入内源性稳定表达系统来表达发夹样核酶。
- Hence, deoxyribozymes rendered nuclease resistant by chemical modification possess that advantage over endogenously produced ribozymes. 相比之下,化学修饰的DNA酶则要比内源性生成的核酶更加耐受核酸酶的作用。
- Firstly, three hammer head ribozymes specific to the fusion point of bcr abl were designed and cloned into a modified in vitro transcription vector pDES. 为此,我们针对bcr?abl 融合位点设计、合成了3 个相邻的锤头状核酶。
- When the product accumulates beyond an optimal amount it binds to a site (ALLOSTERIC SITE) on the enzyme, changing the shape so that it can no longer react with its substrate. 当产物积累超出最佳数量时,它将与酶的一个氨酰基位点(变构位点)结合改变其形状,使其不能长时间与底物发生作用。
- "The L1 ligase appears to use strategies of transition-state stabilization and acid-base catalysis similar to those that exist for natural ribozymes and protein enzymes," he said. “L1连接酶似乎使用了与存在于自然界的核酶和蛋白酶相似的过渡态稳定策略和酸碱催化。”他说。