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- allosteric deoxyribozymes 别构效应脱氧核酶
- Allosteric enzymes may have more than one modulator. 它可以有一个或多个调节物。
- Allosteric enzymes possess an allosteric site in addition to their ACTIVE SITE. 别构酶控制着别构部位和它的活性部位。
- The small molecule causing the conformational change is an allosteric effector. 引起结构变化的小分子叫做变构效应
- Proteins which have two separate but interacting sites are called allosteric proteins. 这种具有两个不同而又相互作用位置的蛋白质叫做变构蛋白质。
- Allosteric site A part of an enzyme to which a specific effector or modulator can be attached. 别构部位:可以结合特定效应物或者调节物的酶的一个部分。
- This paper constructs NOT,AND and XOR gates with deoxyribozymes which contain hairpin-stem-loop structure while molecular beacons are substrates. 文章在分子信标作为底物的情况下,用含有发夹茎环结构的核酶建构非门、与门和异或门。
- Proteins which have two separate but interacting kinding sites are called allosteric proteins. 这种具有两个不同位置而又相互作用的蛋白质叫做变构蛋白质。
- Owing to these properties, a continuous kinetic assay for RNA-cleaving deoxyribozymes could exploit ethidium bromide as an extrinsic fluorescent probe. 大量存在的荧光团还可能影响脱氧核酶催化反应的动力学。
- Recently developed small chemical compounds activate GK by binding to an allosteric site of the enzyme protein. 新近开发的一类小分子化合物与该酶蛋白一个变构位点结合从而激活GK。
- Hence, deoxyribozymes rendered nuclease resistant by chemical modification possess that advantage over endogenously produced ribozymes. 相比之下,化学修饰的DNA酶则要比内源性生成的核酶更加耐受核酸酶的作用。
- With these properties, deoxyribozymes is expected to be a regent for RNA inactivating.So it has potential value in gene therapy to some diseases. 脱氧核酶在切割与其互补的RNA底物分子时具有极高的特异性和切割效率,有望成为新的RNA灭活工具,因此,在一些疾病的基因治疗研究中有潜在的价值。
- Obviously the involvement of "allosteric effects" in the action of growth regulators is highly specific and equally speculative. 在生长调节剂的作用中涉及“变构效应,”这显然是高度特殊又是高度推测性的。
- Many oligomeric proteins are allosteric and known to be self-condensing and play an important role in metabolic control. 许多低聚物蛋白是变构的并且是能自我压缩的,在对于新陈代谢中起着重要的作用。
- But APV and MK-801 were toxic inthemselves, Kyn as an endogenous allosteric antago-nist of the N-methyl-D-asl)artate receptor is low intoxicity. 但APV和MK-801本身有一定毒性。
- A small molecule that when bound to the allosteric site of an enzyme causes either a decrease or an increase in the activity of the enzyme. 效应物,一种小分子,当邻接酶的变构点时会引起酶活动的增加或减少。
- When the product accumulates beyond an optimal amount it binds to a site (ALLOSTERIC SITE) on the enzyme, changing the shape so that it can no longer react with its substrate. 当产物积累超出最佳数量时,它将与酶的一个氨酰基位点(变构位点)结合改变其形状,使其不能长时间与底物发生作用。
- Allosteric enzyme An enzyme whose catalytic activity can be modified by the noncovalent binding of a particular metabolite (a modulator)at a site(the ALLOSTERIC SITE)other than the active site. 别(变)构酶:这种酶除了有活性中心外,还有一个别构中心,当专一性的代谢物非共价的结合到别构中心上时,它的催化活性即发生改变。
- With regard to the manifold applications of RNA-cleaving deoxyribozymes, a demand for techniques is being focused on providing a rapid and high-throughput kinetic characterization of these catalysts. 与其应用密切相关的技术问题为大量、高效的测定脱氧核酶切割底物的动力学性质。
- See allosteric site. 参见allostericsite。