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- P53 gene is localized in the short arm of human chromosome 17. P53基因定位于人类第17号染色体的短臂,野生型P53基因是肿瘤抑制基因。
- After G418 selection, stable wt p53 transformants, TDN p53 transformants and control vector transformants (pNeo) were obtained. 经G418筛选获得稳定的整合了野生型 p5 3的克隆 (wide typep5 3 ,wt p5 3 )、突变型 p5 3克隆 (trans doninantnegativep5 3 ,TDNp5 3 )和空载体克隆 (pNeo)。
- The scientists measured mutations in the P53 gene,the most frequently mutated gene in human cancer. 科学家们对P53基因的突变体进行了测量,该基因是人类患癌症时最经常发生突变的基因。
- The scientists measured mutations in the p53 gene, the most frequently mutated gene in human cancer. 科 学 家 们 对 P53基 因 的 突 变 体 进 行 了 测 量 , 该 基 因 是 人 类 患 癌 症 时 最 经 常 发 生 突 变 的 基 因 。
- The results of PCR-SSCP analysis showed that 2 out of 4 SPA with abnormal exon 8 of p53 gene. PCR-SSCP分析显示,本研究的4例涎腺多形性腺瘤组织中,2例出现第8外显子异常电泳带; 1例出现第6外显子异常条带。
- Conclusbo: It suggsts that ras gene aed p53 gene mutation may be related with L- form infedtbo. 结合提示L型感染参与了ras原癌基因激活和p53抑癌基因的失活。
- AIM:To explore gene mutations of p53 gene in samples of keloid pedigrees and the relation of keloid onset. 目的:探讨瘢痕疙瘩家系样本有无p53基因突变以及与瘢痕疙瘩发病的关系。 方法:实验标本来自南方医科大学南方医院整形外科2005年收集的A和B两个瘢痕疙瘩家系。
- Methods :P53 gene mutation patterns in 20 cases of HCC by polymerase chain reaction (PCR) and PCR prod-ucts sequencing. 方法:应用多聚酶链式反应(PCR)结合PCR产物测序,同时检测肝癌P53蛋白表达。
- Gene mutations in p53 gene exon 11 were identified in all samples,which had the same type and site. p53基因外显子11在所有的被检测样本中均发现突变,而且突变的位点及突变的类型均相同。
- The high mutation rate of p53 gene may indicate that PSH has potentially malignant biological behavior. p53基因的高突变率提示PSH可能具有潜在的恶性生物学行为。
- Mutations in P53 gene or interactions of wild-type p53 protein with E6 protein synthesized by HPV may result in SCCL. P53基因突变或野生型P53蛋白与HPV合成的E6蛋白结合可能会导致肺鳞癌的发生。
- A comparative study on p53 gene mutation in primary human Dukes C col on cancer with that in matched lymph node metastasis. Dukes C期大肠癌原发灶与淋巴结转移灶中p53基因突变的比较
- Objective To ascertain the feasibility of detecting p53 gene mutations for early diagnosis of lung cancer using spu-tum from postbronchoscopy. 目的 探讨纤支镜后痰液标本的p53基因突变检测用于肺癌早期诊断的可行性。
- In 29 cases of ocular adnexal MALT-type, the expression of Ki-67 and p53 gene protein did not correlate with age,sex and location(P >0.05). 29例眼附属器MALT型淋巴瘤在不同的年龄、性别、发病部位Ki-67和p53表达差异无显著性。
- Conclu-sion The above results indicate the value of detecting p53 gene mutation for diagnosis of lung cancer using postbronchoscopic spu-tum. 结论 纤支镜后痰标本p53突变检测对肺癌的早期诊断具有一定价值,可作为肺癌早期诊断的辅助方法之一。
- The mutated P53 protein and mutaion in the sequence of P53 gene were detected simultsneously in BPDE transformed human bronchial epithelium cells. BPDE诱导人气管上皮细胞的转化细胞可同时检测到P53突变蛋白的表达及P53基因序列的突变。
- Objective To investigate the role of mutations of P53 gene in the atypical hyperplasia of bronchus epithelia and carcinogenesis of lung. 摘要目的探讨P53基因突变在肺癌癌前病变(支气管黏膜上皮不典型增生)和肺癌中的作用。
- OBJECTIVE: To testify the relationship between the P53 gene status and chemosensitivity and explore the mechanism of antitumor drug"s resistance. 目的:研究P53基因状况与抗癌化疗敏感性的关系,对抗癌药耐药机制进行探讨。
- Hirotoshi H, Masakazu U, Kazuo F, et al. P53 gene mutations in early colorectal carcinoma. De novo vs adenoma-carcinoma sequence. Int J Cancer1991;64:47-51. 王灏,郁宝铭,郑民华,等.;P53基因突变与大肠癌临床预后的关系
- Objective: To investigate the deletion of p53 gene and amplification of HER-2 oncogene at chromosome 17 in epithelial ovarian carcinoma(EOC) and the clinical significance. 目的:检测卵巢上皮性癌中17号染色体上野生型p53基因缺失与HER-2基因的扩增情况并探讨其临床意义。