When overexpressed of QM, alkalinephosphatase activity and nodule mineralization were both increased in MC3T3-E1from QM overexpression cultures relative to normal expression QM cultures.

• 为了进一步研究QM基因在成骨细胞骨质形成和代谢中的作用；我们构建了真核表达载体pcDNA3.；1/myc-His A/QM并转染到MC3T3-E1中建立过表达QM蛋白的细胞系；研究其表达上调后对细胞的影响。