We optimized the codon usage of wild type HPV 16 L1 gene according to the codon bias of mammalian,and synthesized the full-length optimized L1 gene,named mod.

• 首先按照哺乳动物密码子偏好对野生型HPV16 L1基因进行改造并合成优化基因；命名为mod.；HPV16L1。