Vascular endothelial dysfunction has close relation ship with the development of pulmonary hypertension and prostacyclin analogue, endothelin receptor antagonists are new drug for the treatment.

• 血管内皮功能减退与肺动脉高压的发生发展具有极其密切的关系。前列环素类似物、内皮素受体拮抗药等是新开发的有效治疗肺动脉高压的药物。