Using the optimized condition of amino acid derivatization, we investigated the changes in L- arginine (L-Arg) and L-glutamate (L-Glu) concentration in periaqueductal gray matter (PAG) microdia-lytes of free-moving morphine-withdrawal rats.

• 在此优化衍生条件下,成功检测了清醒吗啡戒断大鼠脑导水管周围灰质(Periaqueductal gray matter,PAG)微透析液中谷氨酸(glutamate,Glu)和精氨酸(arginine,Arg)含量变化。