Unlike a powder or liquid fill, a low fill would not be readily apparent after lyophilization particularly for a biopharmaceutical drug product where the active ingredient may be only a milligram.

• 不象粉末和液体灌装，冻干后的产品不能明显的发现低灌装量。特别是生物药品，它们的活性成分可能仅有几毫克。