Unilateral more incidence of lower limb, foot and leg initial cold, afraid of the cold, numb, intermittent claudication, pain, muscle atrophy began to emerge, Gan Mao peeling and serious ulcers can occur or gangrene.

• 以单侧下肢发病较多，起始足部和小腿发凉，怕冷，麻木，间歇跛行，疼痛，逐渐出现肌肉萎缩，汗毛脱落，严重者可发生溃疡或坏疽。