Two decades have passed since the demonic denizens, Diablo, Mephisto, and Baal, wandered the world of Sanctuary in a vicious rampage to shackle humanity into unholy slavery.

• 自恶魔领主迪亚波罗、墨菲斯托和巴尔开始引发避难所的暴乱，将人性扭曲成他们邪恶的意志已经过去了二十年。