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- Recent researches have demonstrated that the ATPase domain of HSP70 and the tumor antigenic peptide that binds to Hsp70 were the crucial parts eliciting tumor-specific immunity. 最近的研究表明HSP70携带的小肽及其ATPase结构域是HSP70抽提物激活肿瘤特异性免疫反应的关键。
- Methods The tumor antigen peptides from 4T1 breast cancer cells were acquired by freeze thawing method and HSP70-4T1 peptides complex was reconstructed in vitro. 方法冻融法获取BALB/C小鼠4T1乳腺癌细胞抗原肽,体外重组HSP70-4T1抗原肽复合物。
- Methods Tumor antigen peptides from elemene-combo Hca-F cell (HTA) combined with HSP70BCG into HTA-HSP70BCG in vitro. DCs were induced in medium with GM-CSF and IL-4 and pulsed with HTA-HSP70BCG, HTA and HSP70BCG, respectively. 方法来源于小鼠的肝癌Hca-F榄香烯复合疫苗的抗原(HTA)与卡介苗来源的HSP70(HSP70BCG)在体外构建成HTA-HSP70BCG复合物,用GM-CSF和IL-4诱导树突状细胞(DCs),分别用HTA-HSP70BCG、HTA和HSP70BCG对其冲激。
- Tumor antigenic peptide 肿瘤抗原肽
- Xu: It will become a tumor antigen. 徐:它会变成一种肿瘤抗原,
- Somatostatin receptor-like immunoreactivity was in most cases located at the plasma membrane as well as in the cytoplasm of the tumor cells and was completely blocked with antigenic peptide. 良性卵巢上皮肿瘤组织中大部分细胞的胞浆和胞膜都呈强染色,呈棕褐色。
- In vivo and in vitro activation of CTL by murine dendritic cells pulsed with acid eluted tumor antigen peptides 弱酸洗脱提取的肿瘤抗原肽致敏的树突状细胞对CTL的体内外激活效应
- Cytotoxicity Induced by Dendritic Cells Pulsed with Acid Eluted Tumor Antigen Peptides against Bladder Cancer Cell Line 负载酸洗抗原肽的树突状细胞诱导抗膀胱癌的作用
- Methods:Human TSN,inactivated TSN and tumor antigen were prepared. 方法 :制备人肺腺癌A5 4 9细胞的TSN、灭活TSN和冻融抗原 ;
- The binding of antigenic peptide sequences to major histocompatibility complex(MHC) molecules is a prerequisite for stimulation of cytotoxic T cell responses. 抗原多肽序列与主要组织相容性复合体(MHC)分子的结合是引起T细胞免疫应答的先决条件。
- Tumor antigen specific CTLs may prevent metastasis in the LCI-D20 model and prolong the survival time. 肿瘤抗原特异性CTL可以预防LCI-D20模型肝癌发生转移,延长动物存活时间。
- Objective To study the immune response of dendritic cells (DC) modified with tumor antigen and SEB to transplanted tumor in nude mice. 摘要目的研究结肠癌患者外周血树突状细胞(DC)体外诱导后在裸鼠体内的抗癌效应。
- The immune system attacks foreign cells - be they tumor cells, virally infected, or donated by another person - when T lymphocytes recognize antigenic peptides displayed on the cell surface. 当T淋巴细胞识别出细胞表面存在抗原多肽时,免疫系统便将其认为异种细胞,并开始攻击,这些异种细胞包括肿瘤细胞,病毒感染的细胞和来源于捐赠人的细胞。
- The immune system attacks 'foreign' cells - be they tumor cells, virally infected, or donated by another person - when T lymphocytes recognize antigenic peptides displayed on the cell surface. 科学家的惯性思维是,当T淋巴细胞识别“非常态”细胞(肿瘤细胞、病毒感染细胞或者同种异体捐助的细胞)表面提呈的抗原肽时,免疫系统攻击“非常态”细胞。
- Branched multiple antigenic peptide 分支多抗原肽
- Objective To investigate antitumor effects induced by dendritic cells (DCs) pulsed with complex of tumor antigen from elemene-combo tumor cell vaccine-heat shock protein 70 of BCG (HTA-HSP70BCG). 目的观察体外构建的榄香烯复合瘤苗抗原-卡介苗热休克蛋白70复合物(HTA-HSP70BCG)诱导的树突状细胞疫苗的抗肿瘤效应。
- It will become a tumor antigen. 它会变成一种肿瘤抗原。
- Aβ1-15 multiple antigen peptide vaccine Aβ1-15多重抗原肽疫苗
- METHODS: BMDCs were stimulated by CpG ODN in combination with tumor antigen (TAg). The expression of CD80 on BMDC surface was analyzed by FCAS. Level of IL-12 (p70) in supernatants of BMDC culture was detected by ELISA. 方法 :CpGODN联合肿瘤抗原 (TAg)体外刺激BMDC ,流式细胞术检测受刺激BMDC表达CD80的阳性率 ,ELISA检测受刺激BMDC分泌IL - 12 (p70 )的水平 ,MTT法检测活化BMDC刺激T细胞的增殖能力 ,联合CpGODN和TAg体内预激小鼠获得CTL ,检测CTL对肝癌细胞株Hca-F的特异性杀伤作用。
- human soluble antigen peptide 35(HS-Ag P35) 人视网膜可溶性抗原第35段抗原决定簇
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- 深远海浮式风电平台 - deep-sea floating wind power platform
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