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- Total Aristolochic Acid 马兜铃酸
- The method of HPLC/MS analysis of aristolochic acid A (Aris A A) in Chinese traditional patent medicine(CTPM) was established. 建立了中成药中马兜铃酸A的高效液相色谱/质谱检测方法.
- RESULTS: Aristolochic acid has nephrotoxicity,alimentary canal toxicity,carcinogenicity,mutagenicity and genotoxicity. 结果:马兜铃酸具有肾毒性、消化道毒性、致癌性、致突变性和基因毒性。
- Object: To compare the content of Aristolochic acid of different parts in Asarum heterotropoides Fr. 目的:比较不同产地不同部位辽细辛中马兜铃酸的痕量。
- Results The main ADR related to aristolochic acid is nephropathy, urothelial cancer being found on some patients. 结果与马兜铃酸有关的不良反应主要为肾损害,部分病例出现尿道上皮癌。
- Cosyns J P,Dehoux J P,Guiot Y.et al.Chronic aristolochic acid toxicity in rabbits:A model of Chinese herbs nephropathy.Kidney Int,2001,59:2164. 文晓彦;郑法雷;高瑞通;等.;马兜铃酸I诱导人肾小管上皮细胞转分化的作用
- Objective: To investigate the urinary carcinoma in patients with aristolochic acid nephropathy (AAN), in order to improve the levels of diagnosis. 摘要目的：探讨马兜铃酸肾病患者伴发泌尿系肿瘤情况，提高认识和诊断水平。
- To analyse the 44 cases of aristolochic acid nephropathy (AAN) in term of pathogeny, clinical symptoms, laboratory results, and some renal pathology. 摘要从近6年收治的肾小管间质性疾病中，筛选出马兜铃酸肾病患者44例。
- OBJECTIVE To determine the content of Aristolochic Acid A in different parts of Herba cum Radice Asari and in Xuetie Dingchuan Plaster. 目的测定细辛不同药用部位及其制剂中马兜铃酸A的含量。
- Objective:To investigate the urinary carcinoma in patients with aristolochic acid nephropathy(AAN),in order to improve the levels of diagnosis. 目的:探讨马兜铃酸肾病患者伴发泌尿系肿瘤情况,提高认识和诊断水平。
- Method Searching published literatures and website associated with aristolochic acid toxicities both domestic and abroad and analyzing them. 方法通过检索国内外公开发表的文献和各国官方网站,收集与马兜铃酸有关的不良反应病例,分析其安全性。
- Gao YL, Chen YP, Dong HR, et al. Experimental study on renal interstitial fibrosis of chronic aristolochic acid nephropahty in rats. Chin J Nephrol2005;21(1):31-35. 高艳丽;谌贻璞;董鸿瑞;等.;慢性马兜铃酸肾病肾间质纤维化发病机制的初步探讨
- Result:aristolochic acid was founded in 6 species of Aristolochia,and not in the other species of Asarum,Akebia,Clematis,Sinomenium,Stephania,Vladimiric and Aucklandic geneses. 结果:17种相关中药材仅马兜铃属6种可检测出马兜铃酸类成分。 细辛属(Asarum)、木通属(Akebia)、铁线莲属(Clematis)、风龙属(Sinomenium)、千金藤属(Stephania)、川木香属(Vladimiric)及云木香属(Aucklandic)相关植物中均未检出相应成分。
- Based on a great deal of etiological research, scholars in our country alleged it should be named by "Aristolochic Acid Nephropathy"(AAN) rather than CHN. 在大量病因学研究基础上，我国学者提出“中草药肾病”的命名欠妥，应称之为马兜铃酸肾病(Aristolochic Acid Nephropathy，AAN)。
- Objective To compare the contents of aristolochic acid in the fruit and seeds of Asarum heterotropoides Fr.Schmidt var. mandshuricum (Maxim.) Kitag. produced in different places. 摘要目的比较辽细辛果实中不同部位和不同产地辽细辛果实与种子中马兜铃酸A的含量。
- Results:Renal insufficiency caused by AAN was diagnosed in 1 patient after taking the medicine containing aristolochic acid(AA) for a long time(15 years). 结果:长期服用含马兜铃酸药物史,并确诊为马兜铃酸肾病,肾功能不全并发血尿的患者,手术证实肾盂移行细胞癌。
- Methods The contents of aristolochic acid in the fruit and seeds of Asarum heterotropoides Fr.Schmidt var. mandshuricum (Maxim.) Kitag. from different places were tested by HPLC. 方法采用HPLC法对辽细辛果实中不同部位和不同产地辽细辛种子进行马兜铃酸A的含量测定。
- The article induced 9 viewpoints to pathogenesy of nephropathy caused by aristolochic acid and reviewed the clinical stage and curing of aristolochic acid nephropathy. 对药用植物中马兜铃酸导致肾病的发病机制归纳为国内外学者的9种观点,并对马兜铃酸肾病的临床分期和治疗方法作了综述。
- Schmidt ver.Mandshuricum(Maxim.) Kitag contained aristolochic acid A or not by HPLC and MS,and the difference in the reference substance and the sample solution was compared. 方法:采用HPLC与MS分别检测北细辛中的马兜铃酸A,并比较对照品和供试品的检测限。
- The interaction between aristolochic acid and bovine serum albumin (HSA) under physiological conditions was investigated by fluorescence quenching methods. 采用荧光光谱技术研究了模拟生理条件下马兜铃酸与人血清白蛋白(HSA)的相互作用。
