These toxic changes were greatly inhibited by zinc pretreatment in MT+/+ mice heart but not in MT-/-mice. Furthermore,zinc pretreatment significantly inhibited DOX-induced promotion of eNOS in MT+/+ mice while similar effect did not occurr in MT-/-mice.

• Zn预处理能显著降低DOX致MT+/+小鼠O2.；-生成增加以及GSH耗竭；抑制DOX诱导的eNOS表达增强；但在MT-/-小鼠中无此效应。