These results clearly indicate that COX-2 is involved in oral carcinogenesis and NSAID has potential against the postinitiation develeopment of SCCs in MBN-induced hamster oral cancers.

• 综合以上结果，清楚显示COX-2与口腔癌发生有关，并且非类固醇抗发炎药可有效抑制由MBN诱导仓鼠产生口腔鳞状上皮细胞癌的作用。