There was significant difference in the rate of mutation of HBV in nt1896 of patients with high eAg and that of patients with low eAg in patients with HbsAg+/eAg+/cAb+.

• 3 “大三阳”患者中 ；eAg高组nt1896终止变异率与eAg低组间差别有显著性意义 (P <0 0 5 )。