There are indications that the fourth-ranked region, SP140 on chromosome 2, may influence the response to immunodeficiency virus type 1 and so may affect the response to other antigenic challenges.

• 有证据显示排行第四的区域，第2对染色体上的SP140，可能影响对免疫缺失病毒第一型的反应，并因此可能影响对其它抗原刺激的反应。