The use of liposomal drug delivery systems allows the enhancement of water solubility,increases plasma exposure of active lactone forms and tumor accumulation as well as decreass in the toxicity.

• 脂质体传递系统能够增加喜树碱类药物溶解度,延长活性内酯环血浆滞留时间,增加肿瘤靶向性,降低游离药物毒性。