The treatment with IL-12 p35 silenced DCs with anti-CD40L mAb can induce immune tolerance and prolong intestinal allografts survival after transplantation.

• 术前输注供体来源的IL-12 p35 silenced DC联合CD40L mAb,可在一定程度上抑制小肠移植的排斥反应,诱导受体产生免疫耐受。