The trace residues were mapped onto the active site of CaNMT. Trp126,Asn175 and Thr211 are highly conserved trace residues and do not interact with current NMT inhibitors,which are potential novel drug binding sites for the novel inhibitor design.

• 通过对白色念珠菌NMT活性位点中药物结合位点的研究发现,Trp126,Asn175和Thr211是NMT家族的高度保守残基,而且不与已有的抑制剂发生直接的相互作用,因此将是发现新型NMT抑制剂的重要药物结合位点。