The thiophane ring was established via reduction of hemiacetal, tosylation of diol, and double SN2 substitution of ditosylate.

• 第二章设计了以从棕榈籽制备的D-甘露糖为手性源，经聚苯乙烯负载三氯化铁催化异亚丙基化、苯甲酰基保护、选择性水解、聚苯乙烯负载二乙酸碘苯氧化、Wittig-Horner反应引入侧链、催化氢化、一锅法脱苯甲酰基及半缩醛还原、对甲苯磺酸酯化、硫代关环、构建四氢噻吩环；