The team began with a mouse model that carries a partial copy of chromosome 21 as is seen in Down syndrome (trisomy 21) containing 108 genes.

• 该研究团队首先制成了一个小鼠模型，小鼠身上携带了21号染色体的一部分片断，该片断包括108个基因，常可在唐氏综合症（21三体综合征）患者体内发现。