The structural character of the selenocysteine insertion sequences (SECIS), the bioinformatics methods of searching selenoprotein from genome and their research progress are introduced.

• 本文就硒代半胱氨酸插入元件(SECIS)结构特征、从基因组中寻找硒蛋白的生物信息学方法及其研究进展作了简要介绍，并对未来的发展趋势进行了展望。