The selective toxicity of DPH on CGN is likely due to its ability to induce apoptosis of CGN, it is a process involved activation of c-Jun and suppression of the activity of p44/42.

• DPH对体外培养的CGN的神经毒性源于其介导的CGN的凋亡,在此过程中c-Jun的表达及活性被上调,p44/42活性被抑制。