The screening tests for embryotoxicity in vivo are time-consuming and expensive when they are carried out on large number of laboratory animals.

• 为解决胚胎毒性体内筛选方法需要大量的动物及人力、耗时、耗力的问题,介绍了胚胎干细胞试验及其在毒理学发育毒性安全性评价中的应用。