The results suggest that Y1 receptor may mediateNPY-induced anti-nociception, and that the opioid receptors in PAG may also be involved in this process in mononeuropathic rats.

• NPY引起的PWLs增加可被Y1受体拮抗剂和阿片剂所阻断.；结果提示；在大鼠PAG 微量注射NPY可产生明显的镇痛作用