The results of electrochemical study indicate that with the effect of gold nanoparticles, DTIC could sensitively detect the single base mismatch of the DNA sequence, and gold nanoparticles can significantly improve its detection sensitivity.

• 研究结果表明,DTIC作为分子探针可以很好地识别DNA链中存在的单碱基错配,并且金纳米粒子能够大幅度地提高单碱基错配的检测灵敏度。