The results from 1H-MRS suggest the distribution of neuronal loss in ALS, and 1H-MRS can be a quantitative measurement in the evaluation of UMN dysfunction in ALS.

• 1H-MRS技术可以检测ALS病人相关脑区NAA/Cr及Cho/Cr比值与正常人存在显著差别,提示ALS病人脑内确实存在着神经元的变性或缺失,同时表明1H-MRS技术可客观、定量地反映UMN的功能。