The relative risk (RR) for mortality was high in patients having P21 and c erbB 2 co expression. The RR of P21 and c erbB 2 protein positive patients in Dukes A stage was higher than that of P21 and c erbB 2 protein negative patients in Dukes B stage.

• 经多因素分析显示P21和c－erbB－2蛋白表达情况，Dukes分期以及PCNA指数与病人预后有关，两种癌基因蛋白共同表达时病人的死亡相对危险度更高，DukesA期P21或c－erbB－2蛋白阳性病人的死亡相对危险度比DukesB期相应蛋白阴性的病人高。