The relative potency of supernatant increased by 216% and had stable inheritance,after LC47 was treated with repeated multiple mutation with ultraviolet radiation(UV) and diethyl sulphate(DES).

• 经紫外线照射(UV)和硫酸二乙酯(DES)多轮复合诱变,LC47发酵液相对效价较未诱变前提高了216%25,且具有良好的传代稳定性。