The relationship of sustained release rate in vitro of nattokinase tablets to other skeletal materials used,such as the amount of HPMC and PVP,and types of diluents,such as MCC,was studied.

• 结论:以HPMC与PVP作为混合骨架材料、MCC作为稀释剂,具有良好的缓释效果,HPMC,PVP和MCC的用量是影响药物释放速率的重要因素。