The recent advance in chemical nuclease is reviewed, and the mechanisms of hydrolysis or cleavage of phosphate ester. DNA and RNA catalyzed by chemical nuclease are discussed by the way.

• 本文综述了化学核酸酶的研究新进展。讨论了化学核酸酶模型催化磷酸酯的水解反应，DNA和RNA的裂解和水解等反应，并对它催化各类反应的作用机制进行了评述。