The progress of the microbial keratinase gene separation and expression is reviewed.The proplems emerging in the process of heterologous expression of keratinase genes are discussed.

• 综述了微生物角蛋白酶基因分离和表达研究进展，并对角蛋白酶基因在异源表达过程中出现的问题进行了讨论。