The processes for the synthesis of 2-mercapto-5-methoxyimidazo[4 ,5-b]pyridine,the key intermediate for the preparation of imidazo [4,5-b]pvridine PPI,were discussed.

• 系统介绍了该化合物的合成方法,认为以2,6-二溴吡啶为原料的合成2-巯基-5-甲氧基咪唑并[4,5-b]吡啶,是值得重点开发的新工艺。