The present results suggested that chronic ethanol intake could induce insulin resistance and down-regulated the expression of IR, IRS-1and PI-3K mRNA in skeletal muscle could be the molecular mechanism.

• 长期摄入过量酒精可以造成骨骼肌组织IR、IRS-1、PI-3K(p85)mRNA表达的降低,这可能是酒精降低胰岛素敏感性,引起胰岛素抵抗的分子机制。