The positive of 71 cases AT_1 -adrenergic receptor the patients DN with refractory hypertension were divided into two groups (the therapy group of 41 patients and the control group of 30 patients).

• 将AT1受体自身抗体阳性的DN合并难治性高血压患者71例；随机分为两组:对照组(30例):给予卡托普利25mg每日3次；尼群地平20mg每6h1次；氢氯噻嗪12.；5mg每日1次；肠溶阿司匹林100mg每日1次;