The phenotype of fibroblasts in inflammatory strictured bile duct wall changed obviously, quiescent fibroblasts were activated and transformed to myofibroblasts, with massive proliferation.

• 炎性狭窄胆管壁的纤维化增厚明显，其成纤维细胞表型改变，由相对静止转化为功能活跃状态，并进一步向肌成纤维细胞转化，且大量增殖。