The mutation of androgen receptor gene, abnormal phosphorylation and abnormal regulation of co-activators contribute to the formation of androgen-independent prostate cancer.

• 雄激素受体基因突变、多种途径引起的异常磷酸化激活和共激活物的调节失控等是激素非依赖性前列腺癌形成的主要促成因素。