The intracellular domain of TrkA provides the docking sites, most of them with tyrosine residues such as Y499, Y547, Y638, Y634, for many adaptor proteins including Shc, Grb2, SH2-B, etc.

• 胞内区含有多个接头蛋白的结合位点,如Shc、Grb2、SH2-B等,其中Y499、Y547、Y638、Y634等酪氨酸位点对于TrkA受体的激活及信号转导起关键作用。