The initial formation of the polarized state involves signaling cascades that epithelial cells use to orient themselves to sites of cell-cell and cell-matrix contact.

• 上皮细胞通过细胞信号转导途径形成极化初始状态，将自己定位于特定位置，调节细胞与细胞之间、细胞与基质之间的相互作用。