The inhibitory effect of Ado on glutamate-induced epileptiform activities in rat hippocampal neurons is also mediated by adenosine A1-receptor with involvement of ATP-sensitive potassium channels.

• 结果提示: Ado与海马神经元上的A1受体结合后, 引起细胞膜上的ATP敏感性钾通道的开放, 从而对海马神经元自发放电及Glu所致的癫痫样放电呈现抑制作用。