The functional roles of the NaChs were tested by observing the effect of tetrodotoxin, a specific blocker of NaChs, on the intrinsic heart rate of isolated rat working heart.

• 建立大鼠离体灌流心脏模型,观察钠通道特异性阻断剂河豚毒素对离体灌流心脏自发性节律即固有心率的影响。